The OncoguardTM Liver test orders and results

OncoguardTM Liver test ordering

The OncoguardTM Liver test offers the convenience of one simple blood collection that can be performed in your office or an affiliated laboratory. All you need to have on hand at the blood collection site is the Exact Sciences Blood Collection Kit and the OncoguardTM Liver test Requisition Form (RF) if you’re ordering tests manually.

Specimens are collected using the Exact Sciences Blood Collection Kit (kit).


Convenient ordering processes that work with your workflow

The OncoguardTM Liver test can be ordered in one of two ways:

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More detailed information on electronic ordering through EpicCare® LinkTM can be found in the EpicCare® LinkTM Welcome Guide in the Training and Additional Resources section within EpicCare® Link.TM

Download a fillable PDF of the Requisition Form, Statement of Medical Necessity, and ABN form from the Resources page.

Our Customer Care Center can help you with your supply orders for Blood Collection Kits, Requisition Forms, Labels and setting up an EpicCare® LinkTM account. See the Order Supplies section for more details »

Some health plans may require prior authorization for the OncoguardTM Liver test. Prior authorization should be completed prior to specimen collection. A signed Advance Beneficiary Notice of Noncoverage (ABN) is required for standard Medicare plans.


OncoguardTM Liver test results

OncoguardTM Liver test results are generated in a format that’s easy to read and understand and will typically be:

  • Available within a week from the specimens being received in our laboratory
  • Available in a patient’s chart in EpicCare® LinkTM for those providers with an EpicCare® LinkTM account, or
  • Sent via secure fax using the secure fax number included on the Order Requisition Form


Positive result

A positive test result may indicate the presence of HCC. When a positive result is reported, additional clinical assessment to confirm the presence of HCC is suggested (e.g., diagnostic imaging procedures).

Negative result

A negative test result indicates a lower likelihood of presence of HCC. When a negative result is obtained, a 3- to 6-month testing cadence is suggested.

In rare instances, a technical failure or insufficient clinical material in the sample yields an invalid result.

False positive and false negative results are possible with the OncoguardTM Liver test. In the clinical lab validation study, the false positive rate was 13% and the false negative rate was 12%.1


The OncoguardTM Liver test is a simple, yet sophisticated blood test that delivers actionable information with a single assessment.


We are here to support smooth test ordering, collection, processing, and reporting.

Contact the Customer Care Center at 1-844-870-8870 or fill out a form to request a visit with a representative.

Learn about OncoguardTM Liver test insurance and billing

Learn more

References: 1. Chalasani NP, Porter K, Bhattacharya A, Book AJ, Neis BM, Xiong KM, Ramasubramanian TS, Edwards V DK, Chen I, Johnson S, Roberts LR, Kisiel JB, Reddy KR, Singal AG, Olson MC, Bruinsma JJ, Validation of a novel multi-target blood test shows high sensitivity to detect early-stage hepatocellular carcinoma, Clinical Gastroenterology and Hepatology (2021), doi: https://